ITPKC (Inositol-trisphosphate 3-kinase C). active profile 1 user wants this gene increased, 0 users want it decreased Substances That Increase ITPKC.
Phenotype data for mouse gene Itpkc. Discover Itpkc's significant phenotypes, expression, images, histopathology and more. Data for gene Itpkc is all freely available for download.
This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins (1,4,5)P3 to produce a molecule called Ins (1,3,4,5)P4. ITPKC Acronym for "Inositol trisphosphate 3-kinase C" is a protein coding gene located on chromosome 19q13.2. The ITPKC gene encodes as one of three isoenzymes (ITPKA and ITPKB) for a member of the inositol 1,4,5-trisphosphate 3-kinase family. ITPKC has 3,901 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets. Sequence variants and/or copy number variants (deletions/duplications) within the ITPKC gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported.
The ITPKC gene encodes as one of three isoenzymes (ITPKA and ITPKB) for a member of the inositol 1,4,5-trisphosphate 3-kinase family. ITPKC has 3,901 functional associations with biological entities spanning 8 categories (molecular profile, organism, chemical, functional term, phrase or reference, disease, phenotype or trait, structural feature, cell line, cell type or tissue, gene, protein or microRNA) extracted from 80 datasets. Sequence variants and/or copy number variants (deletions/duplications) within the ITPKC gene will be detected with >99% sensitivity. Variants classified as unknown significance (VUS), likely pathogenic, or pathogenic will be reported. Benign and likely benign variants are generally not reported. Expression of ITPKC (IP3-3KC, IP3KC) in cancer tissue. The cancer tissue page shows antibody staining of the protein in 20 different cancers.
Rabbit Polyclonal ITPKC antibody Internal Region for ICC, IF, WB. ITPKC antibody (Inositol-Trisphosphate 3-Kinase C) (Internal Region) Primary Cellular Localization: Nucleus , Cytoplasm; Molecular Weight: 75 kDa; Gene ID: 80271.
The ITPKC gene provides instructions for making one version (isoform) of the inositol 1,4,5-trisphosphate 3-kinase (ITPK) enzyme. This enzyme helps add a cluster of oxygen and phosphorus atoms (a phosphate group) to a molecule called Ins (1,4,5)P3 to produce a molecule called Ins (1,3,4,5)P4. ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase.
2021-03-02
ITPKC (Inositol-Trisphosphate 3-Kinase C) is a Protein Coding gene. Diseases associated with ITPKC include Kawasaki Disease and Coronary Aneurysm. Among its related pathways are superpathway of inositol phosphate compounds and Metabolism.
Genetic polymorphisms of the ITPKC signaling pathway in Kawasaki disease. A major advancement in the genetic study of KD was made by the discovery of
18 Oct 2019 Genetic polymorphisms associated with KD susceptibility and The polymorphisms of the ITPKC gene were significantly associated with KD in
20 Nov 2019 In another study conducted by Kuo et al, they noticed that high-risk genotype patients with combined acquisition of ITPKC gene (rs28493229)
13 Apr 2011 3-kinase C (ITPKC) gene is involved in the susceptibility to. KD. ORAI (also known as CRACM1) is one of the components of store-operated
241, A_51_P507622, Itpkc, ref|NM_181593|ens|ENSMUST00000003850|gb|AK033605|gb|BC013227, 1.87E- 2, Gene expression cluster, Dusp1-/- * LPS vs. Genes are ranked from most upregulated to most downregulated by 3669, Itpkc, Itpkc, Itpkc, chr7:27207169-27228597, Scr, shRPAP1, OK, 3.62821, 5.01309
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Find diseases associated with this biological target and compounds tested against it in bioassay experiments. Summary of ITPKC (IP3-3KC, IP3KC) expression in human tissue. General cytoplasmic and nuclear expression. Description: Homo sapiens inositol-trisphosphate 3-kinase C (ITPKC), mRNA. (from RefSeq NM_025194) RefSeq Summary (NM_025194): This gene encodes a member of the inositol 1,4,5-trisphosphate [Ins(1,4,5)P(3)] 3-kinase family of enzymes that catalyze the phosphorylation of inositol 1,4,5-trisphosphate to 1,3,4,5-tetrakisphosphate.
The ITPKC gene encodes as one of three isoenzymes (ITPKA and ITPKB) for a member of the inositol 1,4,5-trisphosphate 3-kinase family. ITPKC (inositol-trisphosphate 3-kinase C), Authors: Dessen P. Published in: Atlas Genet Cytogenet Oncol Haematol.
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30 Nov 2018 As such, ITPKC, an upstream regulator of SOC entry, is a potential candidate gene for osteoclastogenesis as well. However, the genetic
ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase.This gene that has been associated with Kawasaki disease. Kawasaki disease is an acute febrile illness that involves the inflammation of blood vessels throughout the body. ITPKC (Inositol-Trisphosphate 3-Kinase C) is a Protein Coding gene.
2019-12-07 · [PMID 18084290] ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. [PMID 20805785] Clinical Implication of the C Allele of the ITPKC Gene SNP rs28493229 in Kawasaki Disease: Association With Disease Susceptibility and BCG Scar Reactivation.
The Parkinson’s disease-associated gene ITPKB protects against α-synuclein aggregation by regulating ER-to-mitochondria calcium release Daniel J. Apiccoa,b,1 , Evgeny Shlevkova, Catherine L. Nezicha , David T. Trana , Edward Guilmettec, We aim to study if polymorphisms in the ITPKC gene are associated with the risk of cervical cancer in Taiwanese women. ITPKC rs28493229 C/G, rs890934 G/T, rs2303723 C/T, and rs10420685 A/G polymorphisms were genotyped in a hospital-based study of 465 women with cervical squamous cell carcinoma (CSCC) and 800 age-matched healthy control women. Summaries for ITPKB gene (According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL) About This Sectio RNA in situ RNAscope or Basescope probes for ITPKC in the catalog for Mouse Summary of ITPKC expression in human tissue.
ITPKC is one of 3 human genes that encode for an Inositol-trisphosphate 3-kinase.